Evolutionary Coupling Analysis
Predicted and experimental contacts
Secondary structure from ECs
Known pdb structures
pdb |
chain |
2ly4 |
A |
2rtu |
A |
2yrq |
A |
EC score distribution and threshold
Top ECs
Rank |
Residue 1 |
Amino acid 1 |
Residue 2 |
Amino acid 2 |
EC score |
1 |
154 |
K |
158 |
D |
1.25 |
2 |
108 |
E |
144 |
Y |
1.08 |
3 |
109 |
Y |
132 |
M |
1.08 |
4 |
142 |
Q |
146 |
K |
1.03 |
5 |
106 |
C |
129 |
L |
0.91 |
6 |
143 |
P |
147 |
K |
0.80 |
7 |
99 |
P |
151 |
L |
0.77 |
8 |
128 |
K |
132 |
M |
0.76 |
9 |
131 |
E |
135 |
N |
0.75 |
10 |
109 |
Y |
129 |
L |
0.66 |
11 |
155 |
Y |
159 |
I |
0.66 |
12 |
183 |
K |
187 |
E |
0.62 |
13 |
104 |
L |
151 |
L |
0.61 |
14 |
59 |
K |
63 |
M |
0.61 |
15 |
112 |
K |
116 |
E |
0.58 |
16 |
104 |
L |
147 |
K |
0.57 |
17 |
99 |
P |
103 |
F |
0.57 |
18 |
105 |
F |
136 |
T |
0.56 |
19 |
138 |
A |
145 |
E |
0.56 |
20 |
57 |
K |
62 |
D |
0.55 |
21 |
63 |
M |
67 |
D |
0.55 |
22 |
68 |
K |
72 |
E |
0.55 |
23 |
64 |
A |
68 |
K |
0.55 |
24 |
136 |
T |
140 |
D |
0.54 |
25 |
126 |
A |
130 |
G |
0.54 |
26 |
98 |
P |
155 |
Y |
0.54 |
27 |
152 |
K |
156 |
E |
0.54 |
28 |
63 |
M |
68 |
K |
0.52 |
29 |
147 |
K |
151 |
L |
0.52 |
30 |
101 |
A |
145 |
E |
0.52 |
31 |
182 |
K |
187 |
E |
0.51 |
32 |
56 |
E |
61 |
E |
0.51 |
33 |
56 |
E |
64 |
A |
0.51 |
34 |
122 |
I |
126 |
A |
0.51 |
35 |
69 |
A |
73 |
R |
0.51 |
36 |
181 |
S |
187 |
E |
0.50 |
37 |
56 |
E |
60 |
F |
0.50 |
38 |
59 |
K |
64 |
A |
0.50 |
39 |
111 |
P |
115 |
G |
0.49 |
40 |
159 |
I |
163 |
R |
0.49 |
41 |
155 |
Y |
162 |
Y |
0.49 |
42 |
61 |
E |
65 |
K |
0.48 |
43 |
149 |
A |
153 |
E |
0.48 |
44 |
106 |
C |
126 |
A |
0.48 |
45 |
67 |
D |
71 |
Y |
0.48 |
46 |
106 |
C |
110 |
R |
0.47 |
47 |
160 |
A |
164 |
A |
0.47 |
48 |
105 |
F |
109 |
Y |
0.47 |
49 |
58 |
G |
66 |
A |
0.46 |
50 |
138 |
A |
142 |
Q |
0.46 |
51 |
57 |
K |
68 |
K |
0.46 |
52 |
58 |
G |
64 |
A |
0.46 |
53 |
90 |
K |
94 |
A |
0.46 |
54 |
61 |
E |
66 |
A |
0.45 |
55 |
108 |
E |
147 |
K |
0.45 |
56 |
57 |
K |
61 |
E |
0.45 |
57 |
104 |
L |
144 |
Y |
0.45 |
58 |
99 |
P |
107 |
S |
0.45 |
59 |
180 |
K |
186 |
E |
0.45 |
60 |
57 |
K |
63 |
M |
0.44 |
61 |
59 |
K |
65 |
K |
0.44 |
62 |
58 |
G |
63 |
M |
0.44 |
63 |
61 |
E |
71 |
Y |
0.44 |
64 |
102 |
F |
133 |
W |
0.44 |
65 |
65 |
K |
69 |
A |
0.44 |
66 |
101 |
A |
148 |
A |
0.43 |
67 |
105 |
F |
132 |
M |
0.43 |
68 |
56 |
E |
63 |
M |
0.43 |
69 |
57 |
K |
65 |
K |
0.43 |
70 |
146 |
K |
150 |
K |
0.43 |
71 |
176 |
V |
181 |
S |
0.43 |
72 |
182 |
K |
186 |
E |
0.43 |
73 |
82 |
K |
86 |
K |
0.42 |
74 |
151 |
L |
158 |
D |
0.42 |
75 |
136 |
T |
143 |
P |
0.42 |
76 |
113 |
I |
117 |
H |
0.42 |
77 |
61 |
E |
67 |
D |
0.42 |
78 |
145 |
E |
149 |
A |
0.42 |
79 |
56 |
E |
65 |
K |
0.42 |
80 |
62 |
D |
66 |
A |
0.42 |
81 |
58 |
G |
62 |
D |
0.42 |
82 |
63 |
M |
70 |
R |
0.42 |
83 |
66 |
A |
70 |
R |
0.42 |
84 |
176 |
V |
180 |
K |
0.42 |
85 |
180 |
K |
185 |
K |
0.41 |
86 |
59 |
K |
67 |
D |
0.41 |
87 |
153 |
E |
157 |
K |
0.41 |
88 |
132 |
M |
136 |
T |
0.41 |
89 |
56 |
E |
62 |
D |
0.41 |
90 |
64 |
A |
71 |
Y |
0.41 |
91 |
180 |
K |
184 |
K |
0.41 |
92 |
67 |
D |
74 |
E |
0.41 |
93 |
59 |
K |
66 |
A |
0.40 |
94 |
70 |
R |
74 |
E |
0.40 |
95 |
62 |
D |
67 |
D |
0.40 |
96 |
137 |
A |
143 |
P |
0.40 |
97 |
60 |
F |
64 |
A |
0.40 |
98 |
63 |
M |
69 |
A |
0.40 |
99 |
166 |
G |
170 |
A |
0.40 |
100 |
102 |
F |
130 |
G |
0.40 |
101 |
57 |
K |
69 |
A |
0.40 |
102 |
174 |
G |
179 |
E |
0.39 |
103 |
62 |
D |
68 |
K |
0.39 |
104 |
58 |
G |
65 |
K |
0.39 |
105 |
95 |
P |
162 |
Y |
0.39 |
106 |
98 |
P |
104 |
L |
0.39 |
107 |
177 |
K |
184 |
K |
0.39 |
108 |
75 |
M |
79 |
I |
0.39 |
109 |
69 |
A |
74 |
E |
0.39 |
110 |
167 |
K |
172 |
K |
0.39 |
111 |
61 |
E |
68 |
K |
0.39 |
112 |
60 |
F |
67 |
D |
0.39 |
113 |
56 |
E |
70 |
R |
0.39 |
114 |
66 |
A |
72 |
E |
0.38 |
115 |
95 |
P |
155 |
Y |
0.38 |
116 |
82 |
K |
87 |
K |
0.38 |
117 |
78 |
Y |
82 |
K |
0.38 |
118 |
66 |
A |
71 |
Y |
0.38 |
119 |
63 |
M |
74 |
E |
0.38 |
120 |
58 |
G |
71 |
Y |
0.38 |
121 |
60 |
F |
74 |
E |
0.37 |
122 |
75 |
M |
81 |
P |
0.37 |
123 |
164 |
A |
168 |
P |
0.37 |
124 |
178 |
A |
182 |
K |
0.37 |
125 |
113 |
I |
129 |
L |
0.37 |
126 |
65 |
K |
71 |
Y |
0.37 |
127 |
148 |
A |
152 |
K |
0.37 |
128 |
100 |
S |
106 |
C |
0.37 |
129 |
170 |
A |
177 |
K |
0.37 |
130 |
60 |
F |
71 |
Y |
0.37 |
131 |
60 |
F |
66 |
A |
0.37 |
132 |
102 |
F |
106 |
C |
0.36 |
133 |
99 |
P |
104 |
L |
0.36 |
134 |
56 |
E |
71 |
Y |
0.36 |
135 |
175 |
V |
182 |
K |
0.36 |
136 |
179 |
E |
185 |
K |
0.36 |
137 |
66 |
A |
73 |
R |
0.36 |
138 |
177 |
K |
181 |
S |
0.35 |
139 |
174 |
G |
178 |
A |
0.35 |
140 |
100 |
S |
104 |
L |
0.35 |
141 |
174 |
G |
180 |
K |
0.35 |
142 |
78 |
Y |
83 |
G |
0.35 |
143 |
62 |
D |
70 |
R |
0.35 |
144 |
103 |
F |
126 |
A |
0.35 |
145 |
87 |
K |
91 |
D |
0.35 |
146 |
57 |
K |
66 |
A |
0.35 |
147 |
57 |
K |
64 |
A |
0.35 |
148 |
72 |
E |
79 |
I |
0.35 |
149 |
181 |
S |
186 |
E |
0.35 |
150 |
103 |
F |
130 |
G |
0.34 |
151 |
65 |
K |
75 |
M |
0.34 |
152 |
105 |
F |
129 |
L |
0.34 |
153 |
65 |
K |
73 |
R |
0.34 |
154 |
169 |
D |
173 |
K |
0.34 |
155 |
68 |
K |
74 |
E |
0.34 |
156 |
151 |
L |
155 |
Y |
0.34 |
157 |
1 |
M |
59 |
K |
0.34 |
158 |
123 |
G |
127 |
K |
0.34 |
159 |
60 |
F |
65 |
K |
0.34 |
160 |
105 |
F |
133 |
W |
0.34 |
161 |
67 |
D |
73 |
R |
0.34 |
162 |
87 |
K |
93 |
N |
0.34 |
163 |
100 |
S |
110 |
R |
0.34 |
164 |
71 |
Y |
75 |
M |
0.34 |
165 |
69 |
A |
75 |
M |
0.34 |
166 |
105 |
F |
130 |
G |
0.34 |
167 |
175 |
V |
179 |
E |
0.34 |
168 |
179 |
E |
183 |
K |
0.33 |
169 |
58 |
G |
69 |
A |
0.33 |
170 |
59 |
K |
72 |
E |
0.33 |
171 |
62 |
D |
71 |
Y |
0.33 |
172 |
177 |
K |
182 |
K |
0.33 |
173 |
74 |
E |
78 |
Y |
0.33 |
174 |
127 |
K |
131 |
E |
0.33 |
175 |
65 |
K |
70 |
R |
0.33 |
176 |
81 |
P |
87 |
K |
0.33 |
177 |
73 |
R |
77 |
T |
0.33 |
178 |
173 |
K |
186 |
E |
0.33 |
179 |
105 |
F |
144 |
Y |
0.33 |
180 |
156 |
E |
160 |
A |
0.33 |
181 |
60 |
F |
69 |
A |
0.33 |
182 |
64 |
A |
70 |
R |
0.33 |
183 |
95 |
P |
159 |
I |
0.33 |
184 |
56 |
E |
67 |
D |
0.32 |
185 |
60 |
F |
72 |
E |
0.32 |
186 |
56 |
E |
74 |
E |
0.32 |
187 |
62 |
D |
72 |
E |
0.32 |
Alignment robustness analysis
First most common residue correlation
Second most common residue correlation